J Genomics 2014; 2:68-76. doi:10.7150/jgen.8044

Review

The Sex Chromosomes of Frogs: Variability and Tolerance Offer Clues to Genome Evolution and Function

Jacob W. Malcom, Randal S. Kudra, John H. Malone

Department of Molecular and Cell Biology, University of Connecticut, Storrs, 06269 USA

Abstract

Frog sex chromosomes offer an ideal system for advancing our understanding of genome evolution and function because of the variety of sex determination systems in the group, the diversity of sex chromosome maturation states, the ease of experimental manipulation during early development. After briefly reviewing sex chromosome biology generally, we focus on what is known about frog sex determination, sex chromosome evolution, and recent, genomics-facilitated advances in the field. In closing we highlight gaps in our current knowledge of frog sex chromosomes, and suggest priorities for future research that can advance broad knowledge of gene dose and sex chromosome evolution.

Keywords: Homomorphic, aneuploidy, dosage, compensation, sex determination

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Malcom JW, Kudra RS, Malone JH. The Sex Chromosomes of Frogs: Variability and Tolerance Offer Clues to Genome Evolution and Function. J Genomics 2014; 2:68-76. doi:10.7150/jgen.8044. Available from http://www.jgenomics.com/v02p0068.htm