J Genomics
2014; 2:94-103.
doi:10.7150/jgen.8043 This volumeCite
Review
How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression
Flávio O. Francisco, Bernardo Lemos✉
Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
✉ Corresponding author: Bernardo Lemos, 665 Huntington Avenue, Bldg 2, Rm 219, Harvard School of Public Health, Boston, MA 02115-6021. Email: blemosharvard.edu.
Citation:
Francisco FO, Lemos B. How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. J Genomics 2014; 2:94-103. doi:10.7150/jgen.8043. https://www.jgenomics.com/v02p0094.htm
The Y chromosomes of Drosophila melanogaster and D. simulans contain only a handful of protein-coding genes, which are related to sperm mobility and reproductive fitness. Despite low or absent protein coding polymorphism, the Drosophila Y chromosome has been associated with natural phenotypic variation, including variation in the expression of hundreds to thousands of genes located on autosomes and on the X chromosome. Polymorphisms present in the large blocks of heterochromatin and consisting of differences in the amounts and kinds of sequences for satellite DNA and transposable elements may be the source of this modulation. Here we review the evidence and discuss mechanisms for global epigenetic regulation by repetitious elements in the Y chromosome. We also discuss how the discovery of this new function impacts the current knowledge about Y chromosome origin, its current dynamics, and future fate.
Francisco, F.O., Lemos, B. (2014). How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. Journal of Genomics, 2, 94-103. https://doi.org/10.7150/jgen.8043.
ACS
Francisco, F.O.; Lemos, B. How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. J. Genomics 2014, 2, 94-103. DOI: 10.7150/jgen.8043.
NLM
Francisco FO, Lemos B. How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. J Genomics 2014; 2:94-103. doi:10.7150/jgen.8043. https://www.jgenomics.com/v02p0094.htm
CSE
Francisco FO, Lemos B. 2014. How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression. J Genomics. 2:94-103.