J Genomics 2018; 6:103-112. doi:10.7150/jgen.20581 This volume Cite

Research Paper

Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma

Suriya Narayanan Murugesan1*, Birendra Singh Yadav1*, Pramod Kumar Maurya1*, Amit Chaudhary1*, Swati Singh2*, Ashutosh Mani1*✉

1. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India-211004.
2. Center of Bioinformatics, University of Allahabad, India-211002.
*All authors contributed equally.

Citation:
Murugesan SN, Yadav BS, Maurya PK, Chaudhary A, Singh S, Mani A. Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. J Genomics 2018; 6:103-112. doi:10.7150/jgen.20581. https://www.jgenomics.com/v06p0103.htm
Other styles

File import instruction

Abstract

Graphic abstract

Y-Box Binding protein 1 (YBX-1) is known to be involved in various types of cancers. It's interactors also play major role in various cellular functions. Present work aimed to study the expression profile of the YBX-1 interactors during lung adenocarcinoma (LUAD). The differential expression analysis involved 57 genes from 95 lung adenocarcinoma samples, construction of gene network and topology analysis. A Total of 43 genes were found to be differentially expressed from which 17 genes were found to be down regulated and 26 genes were up-regulated. We observed that Polyadenylate-binding protein 1 (PABPC1), a protein involved in YBX1 translation, is highly correlated with YBX1. The interaction network analysis for a differentially expressed non-coding RNA Growth Arrest Specific 5 (GAS5) suggests that two proteins namely, Growth Arrest Specific 2 (GAS2) and Peripheral myelin protein 22 (PMP22) are potentially involved in LUAD progression. The network analysis and differential expression suggests that Collagen type 1 alpha 2 (COL1A2) can be potential biomarker and target for LUAD.

Keywords: YBX1, regulatory network, lung adenocarcinoma, RNA-Seq.


Citation styles

APA
Murugesan, S.N., Yadav, B.S., Maurya, P.K., Chaudhary, A., Singh, S., Mani, A. (2018). Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. Journal of Genomics, 6, 103-112. https://doi.org/10.7150/jgen.20581.

ACS
Murugesan, S.N.; Yadav, B.S.; Maurya, P.K.; Chaudhary, A.; Singh, S.; Mani, A. Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. J. Genomics 2018, 6, 103-112. DOI: 10.7150/jgen.20581.

NLM
Murugesan SN, Yadav BS, Maurya PK, Chaudhary A, Singh S, Mani A. Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. J Genomics 2018; 6:103-112. doi:10.7150/jgen.20581. https://www.jgenomics.com/v06p0103.htm

CSE
Murugesan SN, Yadav BS, Maurya PK, Chaudhary A, Singh S, Mani A. 2018. Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. J Genomics. 6:103-112.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image