J Genomics 2013; 1:45-55. doi:10.7150/jgen.3996
Obesity Gene Atlas in Mammals
1. Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia;
2. Centre for Mathematical and Computational Biology, Rothamsted Research, Harpenden, Herts, AL5, 2JQ, UK;
3. Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351, USA.
* Authors contributed equally to the work.
Obesity in humans has increased at an alarming rate over the past two decades and has become one of the leading public health problems worldwide. Studies have revealed a large number of genes/markers that are associated with obesity and/or obesity-related phenotypes, indicating an urgent need to develop a central database for helping the community understand the genetic complexity of obesity. In the present study, we collected a total of 1,736 obesity associated loci and created a freely available obesity database, including 1,515 protein-coding genes and 221 microRNAs (miRNAs) collected from four mammalian species: human, cattle, rat, and mouse. These loci were integrated as orthologs on comparative genomic views in human, cattle, and mouse. The database and genomic views are freely available online at:
Keywords: adipogenesis, fat deposition, integratomics, mammals, microRNA (miRNA), obesity.
Kunej T, Jevsinek Skok D, Zorc M, Ogrinc A, Michal JJ, Kovac M, Jiang Z. Obesity Gene Atlas in Mammals. J Genomics 2013; 1:45-55. doi:10.7150/jgen.3996. Available from http://www.jgenomics.com/v01p0045.htm