J Genomics
2015; 3:51-56.
doi:10.7150/jgen.11246 This volumeCite
Research Paper
Genetic Variability of MicroRNA Genes in 15 Animal Species
Minja Zorc, Jana Obsteter, Peter Dovc, Tanja Kunej✉
Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230 Domzale, Slovenia
✉ Corresponding author: Tanja Kunej, Chair of Genetics, animal biotechnology and immunology, Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, Slovenia, Phone: +3861-320-3890; Fax: +3861 7217 888, Email: tanja.kunejuni-lj.siMore
Citation:
Zorc M, Obsteter J, Dovc P, Kunej T. Genetic Variability of MicroRNA Genes in 15 Animal Species. J Genomics 2015; 3:51-56. doi:10.7150/jgen.11246. https://www.jgenomics.com/v03p0051.htm
MicroRNAs (miRNA) are a class of non-coding RNAs important in posttranscriptional regulation of target genes. Previous studies have proven that genetic variability of miRNA genes (miR-SNP) has an impact on phenotypic variation and disease susceptibility in human, mice and some livestock species. MicroRNA gene polymorphisms could therefore represent biomarkers for phenotypic traits also in other animal species. We upgraded our previously developed tool miRNA SNiPer to the version 4.0 which enables the search of miRNA genetic variability in 15 animal genomes: http://www.integratomics-time.com/miRNA-SNiPer. Genome-wide in silico screening (GWISS) of 15 genomes revealed that based on the current database releases, miRNA genes are most polymorphic in cattle, followed by human, fruitfly, mouse, chicken, pig, horse, and sheep. The difference in the number of miRNA gene polymorphisms between species is most probably not due to a biological reason and lack of genetic variability in some species, but to different stage of sequencing projects and differences in development of genomic resource databases in different species. Genome screening revealed several interesting genomic hotspots. For instance, several multiple nucleotide polymorphisms (MNPs) are present within mature seed region in cattle. Among miR-SNPs 46 are present on commercial whole-genome SNP chips: 16 in cattle, 26 in chicken, two in sheep and two in pig. The update of the miRNA SNiPer tool and the generated catalogs will serve researchers as a starting point in designing projects dealing with the effects of genetic variability of miRNA genes.
Zorc, M., Obsteter, J., Dovc, P., Kunej, T. (2015). Genetic Variability of MicroRNA Genes in 15 Animal Species. Journal of Genomics, 3, 51-56. https://doi.org/10.7150/jgen.11246.
ACS
Zorc, M.; Obsteter, J.; Dovc, P.; Kunej, T. Genetic Variability of MicroRNA Genes in 15 Animal Species. J. Genomics 2015, 3, 51-56. DOI: 10.7150/jgen.11246.
NLM
Zorc M, Obsteter J, Dovc P, Kunej T. Genetic Variability of MicroRNA Genes in 15 Animal Species. J Genomics 2015; 3:51-56. doi:10.7150/jgen.11246. https://www.jgenomics.com/v03p0051.htm
CSE
Zorc M, Obsteter J, Dovc P, Kunej T. 2015. Genetic Variability of MicroRNA Genes in 15 Animal Species. J Genomics. 3:51-56.