J Genomics 2015; 3:75-81. doi:10.7150/jgen.12863 This volume

Research Paper

GLAD: an Online Database of Gene List Annotation for Drosophila

Yanhui Hu1✉, Aram Comjean1, Lizabeth A. Perkins1, Norbert Perrimon1,2, Stephanie E. Mohr1

1. Drosophila RNAi Screening Center, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
2. Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

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Hu Y, Comjean A, Perkins LA, Perrimon N, Mohr SE. GLAD: an Online Database of Gene List Annotation for Drosophila. J Genomics 2015; 3:75-81. doi:10.7150/jgen.12863. Available from https://www.jgenomics.com/v03p0075.htm

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We present a resource of high quality lists of functionally related Drosophila genes, e.g. based on protein domains (kinases, transcription factors, etc.) or cellular function (e.g. autophagy, signal transduction). To establish these lists, we relied on different inputs, including curation from databases or the literature and mapping from other species. Moreover, as an added curation and quality control step, we asked experts in relevant fields to review many of the lists. The resource is available online for scientists to search and view, and is editable based on community input. Annotation of gene groups is an ongoing effort and scientific need will typically drive decisions regarding which gene lists to pursue. We anticipate that the number of lists will increase over time; that the composition of some lists will grow and/or change over time as new information becomes available; and that the lists will benefit the scientific community, e.g. at experimental design and data analysis stages. Based on this, we present an easily updatable online database, available at www.flyrnai.org/glad, at which gene group lists can be viewed, searched and downloaded.

Keywords: GLAD, Drosophila, genes