J Genomics 2015; 3:40-50. doi:10.7150/jgen.11015 This volume Cite

Review

The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression

Caiguo Zhang1,✉, Fan Zhang2

1. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA
2. Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, 200433, China

Citation:
Zhang C, Zhang F. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics 2015; 3:40-50. doi:10.7150/jgen.11015. https://www.jgenomics.com/v03p0040.htm
Other styles

File import instruction

Abstract

Eukaryotic genome encodes numerous WD40 repeat proteins, which generally function as platforms of protein-protein interactions and are involved in numerous biological process, such as signal transduction, gene transcriptional regulation, protein modifications, cytoskeleton assembly, vesicular trafficking, DNA damage and repair, cell death and cell cycle progression. Among these diverse functions, genome integrity maintenance and cell cycle progression are extremely important as deregulation of them is clinically linked to uncontrolled proliferative diseases such as cancer. Thus, we mainly summarize and discuss the recent understanding of WD40 proteins and their molecular mechanisms linked to genome stability and cell cycle progression in this review, thereby demonstrating their pervasiveness and importance in cellular networks.

Keywords: WD40 protein, DNA damage, cell death, cell cycle


Citation styles

APA
Zhang, C., Zhang, F. (2015). The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. Journal of Genomics, 3, 40-50. https://doi.org/10.7150/jgen.11015.

ACS
Zhang, C.; Zhang, F. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J. Genomics 2015, 3, 40-50. DOI: 10.7150/jgen.11015.

NLM
Zhang C, Zhang F. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics 2015; 3:40-50. doi:10.7150/jgen.11015. https://www.jgenomics.com/v03p0040.htm

CSE
Zhang C, Zhang F. 2015. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics. 3:40-50.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image